Question · asked by 1 review
Lower total dose radiotherapy (67.2 Gy over 5.6 weeks) vs conventional dose RT: Total mortality
- Population
- People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials eligible where more than 50% of participants had oral cavity or oropharyngeal cancer (or separate data available)
- Intervention
- Lower total dose radiotherapy (67.2 Gy over 5.6 weeks)
- Comparison
- conventional dose RT
- Outcome
- Total mortality
Lower total dose radiotherapy (67.2 Gy over 5.6 weeks) showed no clear difference in total mortality compared with conventional/standard total dose radiotherapy (72 Gy); GRADE not reported.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Lower total dose radiotherapy (67.2 Gy over 5.6 weeks) vs Conventional/standard total dose radiotherapy (72 Gy) Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and… Lower total dose radiotherapy (67.2 Gy over 5.6 weeks) showed no clear difference in total mortality compared with conventional/standard total dose radiotherapy (72 Gy); GRADE not reported. Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy (2010) · Cochrane All outcomes | HR 1.38 [0.83, 2.29] | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy 2010 · Cochrane All outcomes | 2010-07 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.