High vs low or no hyaluronic acid: Live birth rate
High probably leads to higher live birth rate ‐ high vs low or no hyaluronic acid compared with low or no hyaluronic acid (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
High vs low or no hyaluronic acid Live birth rate ‐ high vs low or no hyaluronic acid · couples undergoing embryo transfer High probably leads to higher live birth rate ‐ high vs low or no hyaluronic acid compared with low or no hyaluronic acid (moderate certainty). Hyaluronic acid in embryo transfer media for assisted reproductive technologies (2020) · Cochrane Headline outcomes only | RR 1.21 [1.11, 1.31] | 10 studies · 4066 participants | Moderate |
High vs low or no hyaluronic acid Live birth rate—high versus low or no hyaluronic acid · couples undergoing embryo transfer High probably leads to higher live birth rate—high versus low or no hyaluronic acid compared with low or no hyaluronic acid (moderate certainty). Hyaluronic acid in embryo transfer media for assisted reproductive technologies (2014) · Cochrane Headline outcomes onlyearlier version CD007421.PUB3, superseded | OR 1.41 [1.17, 1.69] | 1950 participants | Moderate |
High vs low or no hyaluronic acid Live birth rate—high versus low hyaluronic acid · couples undergoing embryo transfer High probably leads to higher live birth rate—high versus low hyaluronic acid compared with low or no hyaluronic acid (moderate certainty). Hyaluronic acid in embryo transfer media for assisted reproductive technologies (2014) · Cochrane Headline outcomes onlyearlier version CD007421.PUB3, superseded | OR 1.42 [1.16, 1.73] | 1626 participants | Moderate |
High vs low or no hyaluronic acid Live birth rate—high versus no hyaluronic acid · couples undergoing embryo transfer High showed no clear difference in live birth rate—high versus no hyaluronic acid compared with low or no hyaluronic acid (moderate certainty). Hyaluronic acid in embryo transfer media for assisted reproductive technologies (2014) · Cochrane Headline outcomes onlyearlier version CD007421.PUB3, superseded | OR 1.35 [0.86, 2.12] | 324 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Hyaluronic acid in embryo transfer media for assisted reproductive technologies 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.