Cleft lip and/or palate (CL/P) vs Healthy controls without cleft: Probing pocket depth
- Population
- Individuals assessed for periodontal health (mainly children and adolescents, age >2 years)
- Intervention
- Cleft lip and/or palate (CL/P)
- Comparison
- Healthy controls without cleft
- Outcome
- Probing pocket depth
Persons with orofacial cleft have a greater probing pocket depth than healthy controls (MD 0.88, 95% CI 0.82 to 0.95; low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Orofacial cleft (cleft lip and/or palate) as exposure vs Healthy controls without cleft Probing Pocket Depth (PPD) · Individuals assessed for periodontal health (mainly children and adolescents, age >2 years) · Clinical dental examination; various countries (e.g., Brazil, India, China, Thailand, USA) Persons with orofacial cleft have a greater probing pocket depth than healthy controls (MD 0.88, 95% CI 0.82 to 0.95; low certainty). Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of… (2025) All outcomes | MD 0.88 [0.82, 0.95] | 3 studies · 340 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral health in patients with cleft lip and palate: a systematic literature review and meta-analysis of periodontal and dental disease and… 2025 All outcomes | March 2023 to January 2024 | 30 | Not applicable |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Periodontal Findings in Children and Adolescents with Cleft Lip and/or Palate: A Case-Control Study. · 2021 · included by 1 of these review
- Caries Experience and Periodontal Status in Children and Adolescents with Cleft Lip and Palate. · 2017 · included by 1 of these review
- Distribution of corticotrophin releasing factor activity within the hypothalamic-pituitary complex of rats and cattle. · 1977 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.