Question · asked by 1 review
Heparin plus aspirin vs aspirin: Pre‐eclampsia
- Population
- women with persistent antiphospholipid antibodies and recurrent pregnancy loss
- Intervention
- Heparin plus aspirin
- Comparison
- aspirin
- Outcome
- Pre‐eclampsia
Heparin plus aspirin showed no clear difference in pre‐eclampsia compared with aspirin (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Heparin plus aspirin vs aspirin Pre‐eclampsia · women with persistent antiphospholipid antibodies and recurrent pregnancy loss Heparin plus aspirin showed no clear difference in pre‐eclampsia compared with aspirin (low certainty). Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid… (2020) · Cochrane Headline outcomes only | RR 0.57 [0.1, 3.14] | 2 studies · 82 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy… 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.