Question · asked by 0 reviews
Antidepressants (trazodone 200 mg/day) vs placebo: Relief of burning/discomfort (symptom relief; pain intensity)
- Population
- Patients with burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
- Intervention
- Antidepressants (trazodone 200 mg/day)
- Comparison
- placebo
- Outcome
- Relief of burning/discomfort (symptom relief; pain intensity)
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Trazodone (antidepressant, 200 mg/day) vs Placebo Relief of burning/discomfort (symptom relief; pain intensity) · Patients with burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms · 8 weeks Interventions for treating burning mouth syndrome (2005) · Cochrane All outcomesearlier version CD002779.PUB2, superseded | Eight-week double-blind RCT (T-S 1999). No statistically significant differences between trazodone and placebo at any time point. | 1 study | GRADE not reported |
Trazodone (antidepressant, 200 mg/day) vs Placebo Relief of burning/discomfort (symptom relief; pain intensity) · Patients with burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms · 8 weeks Interventions for treating burning mouth syndrome (2000) · Cochrane All outcomesearlier version CD002779, superseded | Eight-week double-blind RCT (T-S 1999 / Tammiala-Salonen 1999). No statistically significant differences between trazodone and placebo at any time point (pain and pain-related symptoms measured at 2-weekly intervals).… | 1 study | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes | 2015-12 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Antidepressants (trazodone 200 mg/day) vs placebo · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no… · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.