Question · asked by 1 review
First‐line thiazides vs calcium channel blockers: Total serious adverse events Duration: 1.75 to 3 years
- Population
- patients with hypertension
- Intervention
- First‐line thiazides
- Comparison
- calcium channel blockers
- Outcome
- Total serious adverse events Duration: 1.75 to 3 years
First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
First‐line thiazides vs first‐line calcium channel blockers Total serious adverse events Duration: 1.75 to 3 years · adults with hypertension First‐line thiazides showed no clear difference in total serious adverse events Duration: 1.75 to 3 years compared with first‐line calcium channel blockers (low certainty). First‐line diuretics versus other classes of antihypertensive drugs for hypertension (2023) · Cochrane Headline outcomes only | RR 1.09 [0.97, 1.24] | 2 studies · 7204 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.