Question · asked by 0 reviews
RAS inhibitors vs thiazides: Heart failure
- Population
- patients with hypertension
- Intervention
- RAS inhibitors
- Comparison
- thiazides
- Outcome
- Heart failure
RAS inhibitors probably leads to higher total heart failure compared with thiazides (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
RAS inhibitors vs thiazides Total heart failure · people with hypertension RAS inhibitors probably leads to higher total heart failure compared with thiazides (moderate certainty). First‐line drugs inhibiting the renin angiotensin system versus other first‐line antihypertensive drug… (2015) · Cochrane Headline outcomes onlyearlier version CD008170.PUB2, superseded | RR 1.19 [1.07, 1.31] | 1 study · 24309 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| First‐line drugs inhibiting the renin angiotensin system versus other first‐line antihypertensive drug classes for hypertension 2018 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.