Question · asked by 1 review
Summary of findings: liprotamase vs porcine PERT: Pulmonary exacerbations
- Population
- children aged 7 years or over and adults with cystic fibrosis
- Intervention
- Summary of findings: liprotamase
- Comparison
- porcine PERT
- Outcome
- Pulmonary exacerbations
Summary of findings: liprotamase showed no clear difference in pulmonary exacerbations: number of exacerbations compared with porcine PERT (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Summary of findings: liprotamase vs porcine PERT Pulmonary exacerbations: number of exacerbations · children aged 7 years or over and adults with cystic fibrosis Summary of findings: liprotamase showed no clear difference in pulmonary exacerbations: number of exacerbations compared with porcine PERT (low certainty). Pancreatic enzyme replacement therapy for people with cystic fibrosis (2020) · Cochrane Headline outcomes only | OR 0.56 [0.13, 2.45] | 1 study · 128 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Pancreatic enzyme replacement therapy for people with cystic fibrosis 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.