Long‐term red cell transfusion vs hydroxyurea and phlebotomy: Incidence of TIA
- Population
- individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke
- Intervention
- Long‐term red cell transfusion
- Comparison
- hydroxyurea and phlebotomy
- Outcome
- Incidence of TIA
It is very uncertain whether long‐term red cell transfusion changes incidence of TIA compared with hydroxyurea and phlebotomy (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Long‐term red cell transfusion vs hydroxyurea and phlebotomy Incidence of TIA · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent… It is very uncertain whether long‐term red cell transfusion changes incidence of TIA compared with hydroxyurea and phlebotomy (very low certainty). Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease (2020) · Cochrane Headline outcomes only | RR 0.66 [0.25, 1.74] | 1 study · 133 participants | Very low |
Long‐term red cell transfusion vs hydroxyurea and phlebotomy Incidence of TIA · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent… It is very uncertain whether long‐term red cell transfusion changes incidence of TIA compared with hydroxyurea and phlebotomy (very low certainty). Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease (2017) · Cochrane Headline outcomes onlyearlier version CD003146.PUB3, superseded | RR 0.66 [0.25, 1.74] | 1 study · 133 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Long‐term red cell transfusion vs hydroxyurea and phlebotomy · individuals with sickle cell disease who are at risk of a primary stroke who have had… · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.