Summary of findings table ‐ Convalescent plasma vs placebo or usual care: Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28
- Population
- individuals with moderate to severe disease
- Intervention
- Summary of findings table ‐ Convalescent plasma
- Comparison
- placebo or usual care
- Outcome
- Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28
Summary of findings table ‐ Convalescent plasma showed no clear difference in clinical worsening: need for invasive mechanical ventilation, or… compared with placebo or standard care alone (high certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Summary of findings table ‐ Convalescent plasma vs placebo or standard care alone Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · individualswith moderate to severe disease Summary of findings table ‐ Convalescent plasma showed no clear difference in clinical worsening: need for invasive mechanical ventilation, or… compared with placebo or standard care alone (high certainty). Convalescent plasma for people with COVID‐19: a living systematic review (2023) · Cochrane Headline outcomes onlyearlier version CD013600.PUB5, superseded | RR 1.03 [0.97, 1.11] | 6 studies · 14477 participants | High |
Summary of findings table ‐ Convalescent plasma vs placebo or standard care alone Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · individualswith moderate to severe disease Summary of findings table ‐ Convalescent plasma showed no clear difference in clinical worsening: need for invasive mechanical ventilation, or… compared with placebo or standard care alone (high certainty). Convalescent plasma for people with COVID‐19: a living systematic review (2023) · Cochrane Headline outcomes only | RR 1.03 [0.97, 1.11] | 6 studies · 14477 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Convalescent plasma for people with COVID‐19: a living systematic review 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Summary of findings table ‐ Convalescent plasma vs standard plasma · individuals with moderate to severe disease · 1 review
- Summary of findings table ‐ Convalescent plasma vs human immunoglobulin · individuals with moderate to severe disease · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.