Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo: Any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis available]
Lactoferrin supplementation with enteral feeds in combination with… may leads to lower any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis… compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo Any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis available] · prevention of sepsis and necrotizing enterocolitis in preterm infants Lactoferrin supplementation with enteral feeds in combination with… may leads to lower any late‐onset sepsis ‐ All infants [Data on only confirmed sepsis… compared with placebo (low certainty). Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants (2020) · Cochrane Headline outcomes only | RR 0.25 [0.14, 0.46] | 3 studies · 564 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Enteral lactoferrin supplementation for prevention of sepsis and necrotizing enterocolitis in preterm infants 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.