Insulin glargine vs NPH insulin: AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation
Insulin glargine showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Insulin glargine vs NPH insulin AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading to discontinuation Insulin glargine showed no clear difference in AEs other than hypoglycaemia (1) SAE (2) Overall AE (3) AE leading… compared with NPH insulin (moderate certainty). (Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2… (2020) · Cochrane Headline outcomes only | RR 0.98 [0.87, 1.1] | 1 study · 13 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| (Ultra‐)long‐acting insulin analogues versus NPH insulin (human isophane insulin) for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.