An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis: HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks
- Population
- HIV‐infected mothers and their breastfeeding infants
- Intervention
- An extended antiretroviral regimen administered to mothers for 28 weeks
- Comparison
- 1 week of antiretroviral prophylaxis
- Outcome
- HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks
An extended antiretroviral regimen administered to mothers for 28… probably leads to lower HIV transmission or death at 28 weeks among those whose diagnostic… compared with 1 week of antiretroviral prophylaxis (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · HIV‐infected mothers and their breastfeeding infants An extended antiretroviral regimen administered to mothers for 28… probably leads to lower HIV transmission or death at 28 weeks among those whose diagnostic… compared with 1 week of antiretroviral prophylaxis (moderate certainty). Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane Headline outcomes only | RR 0.61 [0.38, 0.96] | 1 study · 1435 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants · HIV‐infected mothers and their breastfeeding infants · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.