Question · asked by 1 review
Aspirin vs placebo: Major bleedinga
- Population
- adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary hypertension were excluded)
- Intervention
- Aspirin
- Comparison
- placebo
- Outcome
- Major bleedinga
Aspirin leads to higher major bleedinga compared with placebo (high certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Aspirin vs placebo Major bleedinga · adults with hypertension (patients with atrial fibrillation, congestive heart failure, pre‐eclampsia or pulmonary… Aspirin leads to higher major bleedinga compared with placebo (high certainty). Antiplatelet agents and anticoagulants for hypertension (2022) · Cochrane Headline outcomes only | OR 1.77 [1.34, 2.32] | 2 studies · 21330 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiplatelet agents and anticoagulants for hypertension 2022 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.