Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone: Attachment change
- Population
- Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender
- Intervention
- Autologous platelet concentrates (APC) + guided tissue regeneration (GTR)
- Comparison
- GTR (guided tissue regeneration) alone
- Outcome
- Attachment change
It is very uncertain whether autologous platelet concentrates (APC) + guided tissue regeneration… changes change in clinical attachment level (CAL) (mm) compared with GTR (guided tissue regeneration) alone (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone Change in clinical attachment level (CAL) (mm) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender · All follow-ups It is very uncertain whether autologous platelet concentrates (APC) + guided tissue regeneration… changes change in clinical attachment level (CAL) (mm) compared with GTR (guided tissue regeneration) alone (very low certainty). Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane All outcomes | MD 0.42 [-0.02, 0.86] | 7 studies · 248 participants | Very low |
Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone Change in clinical attachment level (CAL) (mm) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender · 9 to 12 months Autologous platelet concentrates (APC) + guided tissue regeneration… showed no clear difference in change in clinical attachment level (CAL) (mm) compared with GTR (guided tissue regeneration) alone; GRADE not reported. Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane All outcomes | MD 0.27 [-0.39, 0.93] | 5 studies · 164 participants | GRADE not reported |
Autologous platelet concentrates (APC) + guided tissue regeneration (GTR) vs GTR (guided tissue regeneration) alone Change in clinical attachment level (CAL) (mm) · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender · 3 to 6 months, Split-mouth studies only Autologous platelet concentrates (APC) + guided tissue regeneration… led to higher change in clinical attachment level (CAL) (mm) compared with GTR (guided tissue regeneration) alone; GRADE not reported. Autologous platelet concentrates for treating periodontal infrabony defects (2018) · Cochrane All outcomes | MD 0.54 [0.18, 0.89] | 3 studies · 134 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Autologous platelet concentrates for treating periodontal infrabony defects 2018 · Cochrane All outcomes | 27 February 2018 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.