Any glucocorticoid vs no glucocorticoids or placebo: Clinical pregnancy rate
Glucocorticoids showed no clear difference in clinical pregnancy rate per couple –pregnancy rate per couple… compared with no glucocorticoids or placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Glucocorticoids vs no glucocorticoids or placebo Clinical pregnancy rate per couple –pregnancy rate per couple (primary analysis) · women receiving assisted reproductive technology cycles Glucocorticoids showed no clear difference in clinical pregnancy rate per couple –pregnancy rate per couple… compared with no glucocorticoids or placebo (low certainty). Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles (2022) · Cochrane Headline outcomes only | OR 1.17 [0.95, 1.44] | 13 studies · 1967 participants | Low |
Glucocorticoids vs no glucocorticoids or placebo Clinical pregnancy rate per couple: dosage and timing of glucocorticoids – clinical pregnancy rate: lower dose glucocorticoids · women receiving assisted reproductive technology cycles It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple: dosage and timing of… compared with no glucocorticoids or placebo (very low certainty). Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles (2022) · Cochrane Headline outcomes only | OR 1.2 [0.87, 1.67] | 6 studies · 780 participants | Very low |
Glucocorticoids vs no glucocorticoids or placebo Clinical pregnancy rate per couple: dosage and timing of glucocorticoids – clinical pregnancy rate: higher dose glucocorticoids · women receiving assisted reproductive technology cycles It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple: dosage and timing of… compared with no glucocorticoids or placebo (very low certainty). Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles (2022) · Cochrane Headline outcomes only | OR 1.15 [0.87, 1.5] | 7 studies · 1187 participants | Very low |
Glucocorticoids vs no glucocorticoids or placebo Clinical pregnancy rate per couple: dosage and timing of glucocorticoids – clinical pregnancy rate: glucocorticoids during implantation · women receiving assisted reproductive technology cycles It is very uncertain whether glucocorticoids changes clinical pregnancy rate per couple: dosage and timing of… compared with no glucocorticoids or placebo (very low certainty). Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles (2022) · Cochrane Headline outcomes only | OR 1.17 [0.9, 1.52] | 7 studies · 1246 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Peri‐implantation glucocorticoid administration for assisted reproductive technology cycles 2022 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.