Question · asked by 1 review
Discontinuing cholinesterase inhibitor vs continued cholinesterase inhibitor: Cognitive function
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Discontinued cholinesterase inhibitor vs continued cholinesterase inhibitor Cognitive function (change from baseline, short term) Standardised mean difference (ADAS‐Cog/11, SMMSE, MMSE) · patients with dementia Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia (2021) · Cochrane Headline outcomes only | no estimate extracted | 4 studies · 344 participants | Low |
Discontinuing cholinesterase inhibitor vs continuing cholinesterase inhibitor Cognitive function (change from baseline, long term) SMMSE · patients with dementia Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia (2021) · Cochrane Headline outcomes only | no estimate extracted | 1 study · 108 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.