Question · asked by 1 review
Nitrous oxide/oxygen vs placebo or no intervention: Behaviour
- Population
- Children and adolescents (0 to 16 years) needing dental treatment
- Intervention
- Nitrous oxide/oxygen
- Comparison
- placebo or no intervention
- Outcome
- Behaviour
It is very uncertain whether nitrous oxide/oxygen changes behaviour (Houpt/behavioural score) compared with placebo (including no intervention) (very low certainty).
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 3 · 75%Very low 1 · 25%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Nitrous oxide/oxygen vs Placebo (including no intervention) Behaviour (Houpt/behavioural score) · Children and adolescents (0 to 16 years) needing dental treatment It is very uncertain whether nitrous oxide/oxygen changes behaviour (Houpt/behavioural score) compared with placebo (including no intervention) (very low certainty). Sedation of children undergoing dental treatment (2018) · Cochrane All outcomes | SMD 0.69 [0.13, 1.26] | 1 study · 52 participants | Very low |
Nitrous oxide/oxygen vs Placebo (including no intervention) Behaviour · Children and adolescents (0 to 16 years) needing dental treatment Sedation of children undergoing dental treatment (2012) · Cochrane All outcomesearlier version CD003877.PUB4, superseded | Two trials (Nathan 1988; Veerkamp 1993) reported changes favouring nitrous oxide; no data available from Nathan; could not be pooled. Very weak evidence. Narrative. | 2 studies | GRADE not reported |
Nitrous oxide/oxygen vs Placebo (including no intervention) Behaviour · Children and adolescents (0 to 16 years) needing dental treatment Sedation of children undergoing dental treatment (2006) · Cochrane All outcomesearlier version CD003877.PUB3, superseded | Four studies (Lindsay 1980; Nathan 1988; Primosch 1999; Veerkamp 1993) reported changes favouring nitrous oxide. Narrative; not pooled. | 4 studies | GRADE not reported |
Nitrous oxide/oxygen vs Placebo (including no intervention) Behaviour · Children and adolescents (0 to 16 years) needing dental treatment Sedation of children undergoing dental treatment (2005) · Cochrane All outcomesearlier version CD003877.PUB2, superseded | Four studies (Lindsay 1980; Nathan 1988; Primosch 1999; Veerkamp 1993) all reported changes in behaviour or anxiety favouring nitrous oxide (50:50 to 20:80 N2O:O2). Narrative; not pooled. | 4 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Sedation of children undergoing dental treatment 2018 · Cochrane All outcomes | 22 February 2018 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.