Question · asked by 1 review
Nano-hydroxyapatite (nHA) dentifrice/paste (fluoride-free or fluoridated) vs nHA-free / fluoride-free (negative) control: Mineral loss (transversal microradiography)
- Population
- Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by patients
- Intervention
- Nano-hydroxyapatite (nHA) dentifrice/paste (fluoride-free or fluoridated)
- Comparison
- nHA-free / fluoride-free (negative) control
- Outcome
- Mineral loss (transversal microradiography)
Under remineralizing conditions, nHA produced significantly more remineralization than the negative control (MD 350, 95% CI 179 to 521; very low certainty).
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Nano-hydroxyapatite (nHA) dentifrice/paste (fluoride-free or fluoridated) vs nHA-free / fluoride-free (negative) control Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by… · Median 21 days (range 14-28 days), In situ (intraoral appliance); net-remineralizing model, Net-remineralizing conditions Under remineralizing conditions, nHA produced significantly more remineralization than the negative control (MD 350, 95% CI 179 to 521; very low certainty). Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. (2022) All outcomes | MD 350 [179, 521] | 1 study | Very low |
Nano-hydroxyapatite (nHA) dentifrice/paste (fluoride-free or fluoridated) vs nHA-free / fluoride-free (negative) control Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by… · Median 21 days (range 14-28 days), In situ (intraoral appliance); net-demineralizing model, Net-demineralizing conditions Under demineralizing conditions, nHA did not differ from the fluoride-free control (MD -61, 95% CI -1301 to 1179; no significant difference; very low certainty). Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. (2022) All outcomes | MD -61 [-1301, 1179] | 1 study | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomes | Databases searched up to 30 April 2021 (CENTRAL up to 30 Apr 2021; MEDLINE/PubMed 1946 to 30 Apr 2021; Ovid EMBASE 1947 to 30 Apr 2021) | 10 | Low / Critically Low |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.