Question · asked by 1 review
Morphine via pharmacokinetically based PCA (PKPCA) vs Morphine via patient-controlled analgesia (PCA): Daily mean opiate intake per hour
- Population
- People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis
- Intervention
- Morphine via pharmacokinetically based PCA (PKPCA)
- Comparison
- Morphine via patient-controlled analgesia (PCA)
- Outcome
- Daily mean opiate intake per hour
Morphine via pharmacokinetically based PCA (PKPCA) led to higher daily mean opiate intake per hour compared with morphine via patient-controlled analgesia (PCA); GRADE not reported.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 4 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Morphine via pharmacokinetically based PCA (PKPCA) vs Morphine via patient-controlled analgesia (PCA) Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis Morphine via pharmacokinetically based PCA (PKPCA) led to higher daily mean opiate intake per hour compared with morphine via patient-controlled analgesia (PCA); GRADE not reported. Interventions for treating oral mucositis for patients with cancer receiving treatment (2010) · Cochrane All outcomes | MD 3.60 [1.47, 5.73] | 1 study · 35 participants | GRADE not reported |
Morphine via pharmacokinetically based PCA (PKPCA) vs Morphine via patient-controlled analgesia (PCA) Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis Morphine via pharmacokinetically based PCA (PKPCA) led to higher daily mean opiate intake per hour compared with morphine via patient-controlled analgesia (PCA); GRADE not reported. Interventions for treating oral mucositis for patients with cancer receiving treatment (2007) · Cochrane All outcomesearlier version CD001973.PUB3, superseded | MD 3.6 [1.47, 5.73] | 1 study · 35 participants | GRADE not reported |
Morphine via pharmacokinetically based PCA (PKPCA) vs Morphine via patient-controlled analgesia (PCA) Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis Morphine via pharmacokinetically based PCA (PKPCA) led to higher daily mean opiate intake per hour compared with morphine via patient-controlled analgesia (PCA); GRADE not reported. Interventions for treating oral mucositis for patients with cancer receiving treatment (2004) · Cochrane All outcomesearlier version CD001973.PUB2, superseded | MD 3.6 [1.47, 5.73] | 1 study · 35 participants | GRADE not reported |
Morphine via pharmacokinetically based PCA (PKPCA) vs Morphine via patient-controlled analgesia (PCA) Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis Morphine via pharmacokinetically based PCA (PKPCA) led to higher daily mean opiate intake per hour compared with morphine via patient-controlled analgesia (PCA); GRADE not reported. Interventions for treating oral mucositis for patients with cancer receiving treatment (2001) · Cochrane All outcomesearlier version CD001973, superseded | MD 3.6 [1.47, 5.73] | 1 study · 35 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for treating oral mucositis for patients with cancer receiving treatment 2010 · Cochrane All outcomes | 2010-06 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.