Question · asked by 0 reviews
Amifostine vs placebo/no treatment: Vomiting
- Population
- Patients with cancer receiving chemotherapy and/or radiotherapy
- Intervention
- Amifostine
- Comparison
- placebo/no treatment
- Outcome
- Vomiting
Amifostine led to higher vomiting (adverse effect) compared with placebo/no treatment; GRADE not reported.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 3 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Amifostine vs Placebo/no treatment Vomiting (adverse effect) · Patients with cancer receiving chemotherapy and/or radiotherapy · Median 28 days Amifostine led to higher vomiting (adverse effect) compared with placebo/no treatment; GRADE not reported. Interventions for preventing oral mucositis for patients with cancer receiving treatment (2007) · Cochrane All outcomesearlier version CD000978.PUB3, superseded | RR 5.95 [1.03, 34.29] | 3 studies | GRADE not reported |
Amifostine vs Placebo/no treatment Vomiting (adverse effect) · Patients with cancer receiving chemotherapy and/or radiotherapy · Median 28 days Amifostine led to higher vomiting (adverse effect) compared with placebo/no treatment; GRADE not reported. Interventions for preventing oral mucositis for patients with cancer receiving treatment (2006) · Cochrane All outcomesearlier version CD000978.PUB2, superseded | RR 5.95 [1.03, 34.29] | 3 studies | GRADE not reported |
Amifostine vs Placebo/no treatment Vomiting (adverse effect) · Patients with cancer receiving chemotherapy and/or radiotherapy · Median 28 days Amifostine led to higher vomiting (adverse effect) compared with placebo/no treatment; GRADE not reported. Interventions for preventing oral mucositis for patients with cancer receiving treatment (2003) · Cochrane All outcomesearlier version CD000978, superseded | RR 5.92 [1.03, 33.91] | 3 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for preventing oral mucositis for patients with cancer receiving treatment 2011 · Cochrane All outcomes | 2011-02 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Amifostine vs no treatment/placebo · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head… · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.