Aldosterone antagonists vs placebo or usual care: AKI
Aldosterone antagonists probably leads to higher AKI compared with placebo or standard care (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Aldosterone antagonists vs placebo or standard care AKI · proteinuric CKD Aldosterone antagonists probably leads to higher AKI compared with placebo or standard care (moderate certainty). Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression… (2020) · Cochrane Headline outcomes only | RR 2.04 [1.05, 3.97] | 5 studies · 1446 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.