Strong opioids vs placebo: At least 50% reduction in pain
It is very uncertain whether strong opioids changes at least 50% of pain relief compared with placebo (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Strong opioids vs placebo At least 50% of pain relief · people with chronic low‐back pain It is very uncertain whether strong opioids changes at least 50% of pain relief compared with placebo (very low certainty). Opioids compared to placebo or other treatments for chronic low‐back pain (2013) · Cochrane Headline outcomes only | OR 1.89 [1.34, 2.66] | 2 studies · 750 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Opioids compared to placebo or other treatments for chronic low‐back pain 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.