Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration: Pre‐eclampsia
- Population
- pregnant women and their infants..
- Intervention
- Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration
- Comparison
- Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration
- Outcome
- Pre‐eclampsia
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Pre-eclampsia: OR 0.56 (95% CI 0.39 to 0.80), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration Pre-eclampsia · Pregnant women and their offspring Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Pre-eclampsia: OR 0.56 (95% CI 0.39 to 0.80), statistically significant. Umbrella review outcome-level evidence grade: No conclusion. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of… (2014) All outcomes | OR 0.56 [0.39, 0.80] | 9 studies · 3230 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised… 2014 All outcomes | 11 October 2013 | 55 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.