Question · asked by 1 review
Caries-associated bacterial biofilm vs Sound/control tissue (sound dentin, sound root, or enamel caries): Bacterial collagenolytic protease gene expression
- Population
- Human ex vivo carious lesions / caries-associated biofilm
- Intervention
- Caries-associated bacterial biofilm
- Comparison
- Sound/control tissue (sound dentin, sound root, or enamel caries)
- Outcome
- Bacterial collagenolytic protease gene expression
Genes encoding bacterial collagenolytic proteases were detected/overexpressed in coronal and root caries (ungraded; GRADE not feasible).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Caries-associated bacterial biofilm vs Sound/control tissue (sound dentin, sound root, or enamel caries) Bacterial collagenolytic protease gene expression · Human ex vivo carious lesions / caries-associated biofilm · Ex vivo (extracted teeth / clinical carious or biofilm samples) Genes encoding bacterial collagenolytic proteases were detected/overexpressed in coronal and root caries (ungraded; GRADE not feasible). Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | Genes coding for bacterial collagenolytic proteases were significantly expressed/overrepresented in coronal (Simon-Soro et al., 2013) and root (Dame-Teixeira et al., 2018: 42 proteases differentially expressed, 18… | 2 studies · 25 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.