Chloral hydrate oral (50 mg/kg + 50 mg/kg) vs hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg): Proportion of children who had sedation failure or inadequate level of sedation
Chloral hydrate oral (50 mg/kg + 50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg) (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Chloral hydrate oral (50 mg/kg + 50 mg/kg) vs hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg) Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures Chloral hydrate oral (50 mg/kg + 50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg) (low certainty). Chloral hydrate as a sedating agent for neurodiagnostic procedures in children (2021) · Cochrane Headline outcomes only | RR 0.33 [0.11, 1.01] | 1 study · 282 participants | Low |
Chloral hydrate oral (50 mg/kg + 50 mg/kg) vs hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg) Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures Chloral hydrate oral (50 mg/kg + 50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with hydroxyzine hydrochloride oral (1 mg/kg + 1 mg/kg) (low certainty). Chloral hydrate as a sedating agent for neurodiagnostic procedures in children (2017) · Cochrane Headline outcomes onlyearlier version CD011786.PUB2, superseded | RR 0.33 [0.11, 1.01] | 1 study · 282 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Chloral hydrate as a sedating agent for neurodiagnostic procedures in children 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.