Question · asked by 1 review
Multiple LTF gene variants (joint / gene-based) vs Caries-free controls: Dental caries
- Population
- Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
- Intervention
- Multiple LTF gene variants (joint / gene-based)
- Comparison
- Caries-free controls
- Outcome
- Dental caries
A gene-based analysis indicated that multiple LTF variants were jointly associated with dental caries risk (weighted TPM P = 0.0007; no pooled effect estimate; ungraded).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Multiple LTF gene variants (joint / gene-based) vs Caries-free controls Dental caries · Human subjects with dental caries and caries-free controls · Brazil; United States; European countries; China, Gene-based joint association (LTF) A gene-based analysis indicated that multiple LTF variants were jointly associated with dental caries risk (weighted TPM P = 0.0007; no pooled effect estimate; ungraded). The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based… (2020) All outcomes | P-value (gene-based, weighted TPM) 0.0007 | Not reported | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| The association between genetic variants in lactotransferrin and dental caries: a meta- and gene-based analysis. 2020 All outcomes | December 5, 2019 (papers published before this date) | 6 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.