Continuous platinum infusion vs bolus platinum infusion: Adverse effects: toxic death (no definition provided)
Continuous platinum infusion showed no clear difference in adverse effects: toxic death (no definition provided) compared with bolus platinum infusion (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Continuous platinum infusion vs bolus platinum infusion Adverse effects: toxic death (no definition provided) · children with cancer treated with platinum‐based therapy Continuous platinum infusion showed no clear difference in adverse effects: toxic death (no definition provided) compared with bolus platinum infusion (low certainty). Different infusion durations for preventing platinum‐induced hearing loss in children with cancer (2020) · Cochrane Headline outcomes only | RR 1.12 [0.07, 17.31] | 1 study · 91 participants | Low |
Continuous platinum infusion vs bolus platinum infusion Adverse effects: toxic death (no definition provided) · children with cancer treated with platinum‐based therapy Continuous platinum infusion showed no clear difference in adverse effects: toxic death (no definition provided) compared with bolus platinum infusion (low certainty). Different infusion durations for preventing platinum‐induced hearing loss in children with cancer (2018) · Cochrane Headline outcomes onlyearlier version CD010885.PUB4, superseded | RR 1.12 [0.07, 17.31] | 1 study · 91 participants | Low |
Continuous platinum infusion vs bolus platinum infusion Adverse effects: toxic death (no definition provided) · children with cancer treated with platinum‐based therapy Continuous platinum infusion showed no clear difference in adverse effects: toxic death (no definition provided) compared with bolus platinum infusion (low certainty). Different infusion durations for preventing platinum‐induced hearing loss in children with cancer (2016) · Cochrane Headline outcomes onlyearlier version CD010885.PUB3, superseded | RR 1.12 [0.07, 17.31] | 1 study · 91 participants | Low |
Continuous platinum infusion vs bolus platinum infusion Adverse effects: toxic death (no definition provided) · children with cancer treated with platinum‐based therapy Continuous platinum infusion showed no clear difference in adverse effects: toxic death (no definition provided) compared with bolus platinum infusion (low certainty). Different infusion durations for preventing platinum‐induced hearing loss in children with cancer (2014) · Cochrane Headline outcomes onlyearlier version CD010885.PUB2, superseded | RR 1.12 [0.07, 17.31] | 1 study · 91 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Different infusion durations for preventing platinum‐induced hearing loss in children with cancer 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.