Question · asked by 1 review
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs placebo or usual care: Adverse effects
- Population
- Critically ill patients (adults and children) receiving mechanical ventilation in ICU
- Intervention
- Chlorhexidine (mouthrinse or gel), as part of oral hygiene care
- Comparison
- placebo or usual care
- Outcome
- Adverse effects
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 1 · 33.3%Very low 2 · 66.7%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs Placebo or usual care Adverse effects · Critically ill patients (adults and children) receiving mechanical ventilation in ICU Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia (2020) · Cochrane All outcomes | Adverse effects: information from 2 studies; one stated there were none, the other reported mild reversible irritation of the oral mucosa; very low certainty. There was a lack of evidence about adverse effects. | 2 studies | Very low |
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs Placebo or usual care Adverse effects · Critically ill patients (adults and children) receiving mechanical ventilation in ICU Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia (2016) · Cochrane All outcomesearlier version CD008367.PUB3, superseded | Adverse effects: information from 2 studies; one stated there were none, the other reported mild reversible irritation of the oral mucosa; very low certainty. | 2 studies | Very low |
Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs Placebo or usual care Adverse effects · Critically ill patients (adults and children) receiving mechanical ventilation in ICU Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia (2013) · Cochrane All outcomesearlier version CD008367.PUB2, superseded | Adverse effects: 3 studies reported; Bellissimo-Rodrigues 2009 unpleasant taste (3 chlorhexidine vs 5 placebo); Tantipong 2008 mild reversible oral mucosa irritation in 10% chlorhexidine vs 1% control; Berry 2011 none.… | 3 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral hygiene care for critically ill patients to prevent ventilator‐associated pneumonia 2020 · Cochrane All outcomes | 2020-02 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.