Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment: Opioid use
It is very uncertain whether full or partial opioid agonist maintenance changes self‐reported opioid use at treatment completion compared with placebo, detoxification only or psychological treatment… (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment Self‐reported opioid use at treatment completion · pharmaceutical opioid dependent people It is very uncertain whether full or partial opioid agonist maintenance changes self‐reported opioid use at treatment completion compared with placebo, detoxification only or psychological treatment… (very low certainty). Opioid agonist treatment for people who are dependent on pharmaceutical opioids (2022) · Cochrane Headline outcomes only | RR 0.63 [0.39, 1.01] | 4 studies · 276 participants | Very low |
Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment Opioid use · pharmaceutical opioid dependent people Full or partial opioid agonist maintenance may leads to lower opioid use compared with placebo, detoxification only or psychological treatment… (low certainty). Opioid agonist treatment for people who are dependent on pharmaceutical opioids (2022) · Cochrane Headline outcomes only | RR 0.66 [0.52, 0.84] | 4 studies · 270 participants | Low |
Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment Self reported opioid use at treatment completion · pharmaceutical opioid dependent people Full or partial opioid agonist maintenance may leads to lower self reported opioid use at treatment completion compared with placebo, detoxification only or psychological treatment… (low certainty). Opioid agonist treatment for people who are dependent on pharmaceutical opioids (2016) · Cochrane Headline outcomes onlyearlier version CD011117.PUB2, superseded | RR 0.54 [0.31, 0.93] | 3 studies · 204 participants | Low |
Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment Opioid use · pharmaceutical opioid dependent people Full or partial opioid agonist maintenance may leads to lower opioid use compared with placebo, detoxification only or psychological treatment… (low certainty). Opioid agonist treatment for people who are dependent on pharmaceutical opioids (2016) · Cochrane Headline outcomes onlyearlier version CD011117.PUB2, superseded | RR 0.63 [0.43, 0.91] | 3 studies · 206 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Opioid agonist treatment for people who are dependent on pharmaceutical opioids 2022 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.