Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract: Mortality before hospital discharge
Modified bovine minced lung surfactant extract probably leads to higher mortality prior to hospital discharge (from any cause) compared with porcine minced lung surfactant extract (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract Mortality prior to hospital discharge (from any cause) · Preterm infants for treatment of RDS Modified bovine minced lung surfactant extract probably leads to higher mortality prior to hospital discharge (from any cause) compared with porcine minced lung surfactant extract (moderate certainty). Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome… (2015) · Cochrane Headline outcomes only | RR 1.44 [1.04, 2] | 9 studies · 901 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Comparison of animal‐derived surfactants for the prevention and treatment of respiratory distress syndrome in preterm infants 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.