Question · asked by 1 review
Ataluren vs placebo: Mortality rate
- Population
- adults and children with CF with at least one class I mutation (PTC)
- Intervention
- Ataluren
- Comparison
- placebo
- Outcome
- Mortality rate
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Ataluren vs placebo Mortality rate · adults and children with CF with at least one class I mutation (PTC) Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for… (2023) · Cochrane Headline outcomes only | no estimate extracted | 2 studies · 518 participants | High |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Ataluren and similar compounds (specific therapies for premature termination codon class I mutations) for cystic fibrosis 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.