Question · asked by 1 review
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486: Dental caries susceptibility
- Population
- Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
- Intervention
- CT + TT genotype (T-allele carriers) of AMELX rs17878486
- Comparison
- CC genotype of AMELX rs17878486
- Outcome
- Dental caries susceptibility
The CT + TT genotype (T-allele carriers) of AMELX rs17878486 was associated with increased dental caries risk (CT + TT vs CC model: OR 5.72, 95% CI 2.83-11.59) after excluding the outlier study (Ergoz 2014); certainty not graded.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 9 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Sensitivity: study Ergoz 2014 excluded The CT + TT genotype (T-allele carriers) of AMELX rs17878486 was associated with increased dental caries risk (CT + TT vs CC model: OR 5.72, 95% CI 2.83-11.59) after excluding the outlier study (Ergoz 2014); certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 5.72 [2.83, 11.59] | 3 studies | GRADE not reported |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Control group: Caries-free No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs17878486 and dental caries susceptibility (CT + TT vs CC model: OR 2.03, 95% CI 0.10-42.44) in the Control group: Caries-free subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 2.03 [0.10, 42.44] | 2 studies | GRADE not reported |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Overall No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs17878486 and dental caries susceptibility (CT + TT vs CC model: OR 2.30, 95% CI 0.51-10.33); certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 2.30 [0.51, 10.33] | 4 studies · 442 participants | GRADE not reported |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Control group: Low caries The CT + TT genotype (T-allele carriers) of AMELX rs17878486 was associated with increased dental caries risk (CT + TT vs CC model: OR 3.43, 95% CI 1.21-9.75) in the Control group: Low caries subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 3.43 [1.21, 9.75] | 2 studies | GRADE not reported |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Ethnicity: Asian No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs17878486 and dental caries susceptibility (CT + TT vs CC model: OR 0.89, 95% CI 0.04-22.53) in the Ethnicity: Asian subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 0.89 [0.04, 22.53] | 1 study | GRADE not reported |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Ethnicity: Mixed The CT + TT genotype (T-allele carriers) of AMELX rs17878486 was associated with increased dental caries risk (CT + TT vs CC model: OR 4.03, 95% CI 1.27-12.75) in the Ethnicity: Mixed subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 4.03 [1.27, 12.75] | 1 study | GRADE not reported |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Age group: Children No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs17878486 and dental caries susceptibility (CT + TT vs CC model: OR 2.65, 95% CI 0.49-14.35) in the Age group: Children subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 2.65 [0.49, 14.35] | 3 studies | GRADE not reported |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Age group: Adults No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs17878486 and dental caries susceptibility (CT + TT vs CC model: OR 0.89, 95% CI 0.04-22.53) in the Age group: Adults subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 0.89 [0.04, 22.53] | 1 study | GRADE not reported |
CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486 Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls) · Case-control genetic association studies (multiple countries), Ethnicity: Caucasian No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs17878486 and dental caries susceptibility (CT + TT vs CC model: OR 2.03, 95% CI 0.10-42.44) in the Ethnicity: Caucasian subgroup; certainty not graded. Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. (2020) All outcomes | OR 2.03 [0.10, 42.44] | 2 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis. 2020 All outcomes | Up to October 2019 | 16 | Not applicable |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls · 1 review
- CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype · Ethnicity: Asian (n=1) individuals with caries/high caries and controls · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.