RotaTeq vs placebo: All serious adverse events
RotaTeq showed no clear difference in all serious adverse events compared with placebo (high certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
RotaTeq vs placebo All serious adverse events · children RotaTeq showed no clear difference in all serious adverse events compared with placebo (high certainty). Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only | RR 0.92 [0.84, 1.01] | 5 studies · 70690 participants | High |
RotaTeq vs placebo All serious adverse events · children It is very uncertain whether rotaTeq changes all serious adverse events compared with placebo (very low certainty). Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only | RR 0.66 [0.14, 3.17] | 2 studies · 4082 participants | Very low |
RotaTeq vs placebo All serious adverse events · children RotaTeq showed no clear difference in all serious adverse events compared with placebo (moderate certainty). Vaccines for preventing rotavirus diarrhoea: vaccines in use (2021) · Cochrane Headline outcomes only | RR 0.99 [0.72, 1.36] | 4 studies · 7730 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Vaccines for preventing rotavirus diarrhoea: vaccines in use 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.