Question · asked by 1 review
Clobetasol propionate 0.025% microspheres vs Clobetasol propionate 0.025% ointment: Pain (mean score)
- Population
- People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
- Intervention
- Clobetasol propionate 0.025% microspheres
- Comparison
- Clobetasol propionate 0.025% ointment
- Outcome
- Pain (mean score)
Clobetasol propionate 0.025% microspheres led to higher pain (mean score) compared with clobetasol propionate 0.025% ointment; GRADE not reported.
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Clobetasol propionate 0.025% microspheres vs Clobetasol propionate 0.025% ointment Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment Clobetasol propionate 0.025% microspheres led to higher pain (mean score) compared with clobetasol propionate 0.025% ointment; GRADE not reported. Interventions for treating oral lichen planus: corticosteroid therapies (2020) · Cochrane All outcomes | MD 1.83 [0.80, 2.86] | 1 study · 45 participants | GRADE not reported |
Clobetasol propionate 0.025% microspheres vs Clobetasol propionate 0.025% ointment Pain (mean score) · Patients with a clinical and histological diagnosis of symptomatic oral lichen planus (OLP); not concurrently taking… Interventions for treating oral lichen planus: corticosteroid therapies (2011) · Cochrane All outcomesearlier version CD001168.PUB2, superseded | Campisi 2004: microsphere formulation of clobetasol 0.025% reported lower pain scores than standard ointment (favours microspheres) | 1 study · 45 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes | 2019-02 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.