Question · asked by 0 reviews
Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo): Number of minor postoperative bleeding episodes
- Population
- People of all ages on VKA or DOAC treatment undergoing oral or dental procedures (therapeutic INR 2.0 to 4.0; people using acetylsalicylic acid excluded)
- Intervention
- Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid)
- Comparison
- Placebo, no intervention or usual care (with or without placebo)
- Outcome
- Number of minor postoperative bleeding episodes
The review found no eligible studies for this question.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antifibrinolytic agents (tranexamic acid (TXA) or epsilon aminocaproic acid (EACA)) at any dose, route (topical, oral or intravenous), frequency or duration; started before, during or after the procedure vs Placebo, or no intervention, or usual care with or without placebo Number of minor postoperative bleeding episodes · People of all ages on VKA or DOAC treatment undergoing oral or dental procedures (therapeutic INR 2.0 to 4.0; people… · Postoperative up to 10 days (immediate <24 h; delayed 24 h to 10 days) The review found no eligible studies for this question. Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral… (2016) · Cochrane All outcomesearlier version CD012293, superseded | no estimate extracted | 0 studies | No studies found |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or dental extractions 2018 · Cochrane All outcomes | 2018-02 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo) · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions · 1 review
- Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo) · People with hemophilia (A or B) undergoing oral or dental procedures · 0 reviews
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.