Summary of findings table ‐ Fitusiran prophylaxis vs on‐demand therapy: Proportion with zero bleeds
- Population
- people without inhibitors
- Intervention
- Summary of findings table ‐ Fitusiran prophylaxis
- Comparison
- on‐demand therapy
- Outcome
- Proportion with zero bleeds
Summary of findings table ‐ Fitusiran prophylaxis probably leads to higher proportion with zero bleeds compared with on‐demand therapy (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Summary of findings table ‐ Fitusiran prophylaxis vs on‐demand therapy Proportion with zero bleeds · people without inhibitors Summary of findings table ‐ Fitusiran prophylaxis probably leads to higher proportion with zero bleeds compared with on‐demand therapy (moderate certainty). Non‐clotting factor therapies for preventing bleeds in people with congenital hemophilia A or B (2024) · Cochrane Headline outcomes only | RR 8.1 [2.04, 32.11] | 1 study · 119 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Non‐clotting factor therapies for preventing bleeds in people with congenital hemophilia A or B 2024 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Summary of findings table ‐ Fitusiran prophylaxis vs on‐demand therapy · people with inhibitors · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.