High‐dose vs standard‐dose strategies: Side effects (tachycardia, agitation, or feed intolerance) leading to a reduction in dose or withholding of caffeine
It is very uncertain whether high‐dose changes side effects (tachycardia, agitation or feed intolerance) leading to… compared with standard‐dose strategies (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
High‐dose vs standard‐dose strategies Side effects (tachycardia, agitation or feed intolerance) leading to a reduction in dose or withholding of caffeine: high‐loading and high‐maintenance dose standard‐loading and standard‐maintenance dose · preterm infants with or at risk for apnea of prematurity It is very uncertain whether high‐dose changes side effects (tachycardia, agitation or feed intolerance) leading to… compared with standard‐dose strategies (very low certainty). Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity (2023) · Cochrane Headline outcomes only | RR 1.92 [0.53, 6.9] | 2 studies · 150 participants | Very low |
High‐dose vs standard‐dose strategies Side effects (tachycardia, agitation, or feed intolerance) leading to a reduction in dose or withholding of caffeine · preterm infants with or at risk for apnea of prematurity The review found no eligible studies for this question. Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity (2023) · Cochrane Headline outcomes only | no estimate extracted | Not reported | No studies found |
High‐dose vs standard‐dose strategies Side effects (tachycardia, agitation, or feed intolerance) leading to a reduction in dose or withholding of caffeine · preterm infants with or at risk for apnea of prematurity High‐dose showed no clear difference in side effects (tachycardia, agitation, or feed intolerance) leading… compared with standard‐dose strategies (low certainty). Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity (2023) · Cochrane Headline outcomes only | RR 1.66 [0.86, 3.23] | 5 studies · 593 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity 2023 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.