Are disease‐modifying drugs for a first attack suggestive of multiple sclerosis (MS) effective and safe vs placebo?: Discontinuation of medication due to adverse events
It is very uncertain whether are disease‐modifying drugs for a first attack suggestive of… changes withdrawls or drug discontinuation due to adverse events during 24… compared with placebo? (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Are disease‐modifying drugs for a first attack suggestive of multiple sclerosis (MS) effective and safe vs placebo? Withdrawls or drug discontinuation due to adverse events during 24 months of treatment Participants: N = 2693 (5 RCTs) It is very uncertain whether are disease‐modifying drugs for a first attack suggestive of… changes withdrawls or drug discontinuation due to adverse events during 24… compared with placebo? (very low certainty). Treatment with disease‐modifying drugs for people with a first clinical attack suggestive of multiple… (2017) · Cochrane Headline outcomes only | OR 2.43 [0.91, 6.49] | Not reported | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Treatment with disease‐modifying drugs for people with a first clinical attack suggestive of multiple sclerosis 2017 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.