Question · asked by 1 review
Outer carious dentin (by lesion depth/location) vs Inner carious dentin: MMP-8 location/presence
- Population
- Human carious dentin
- Intervention
- Outer carious dentin (by lesion depth/location)
- Comparison
- Inner carious dentin
- Outcome
- MMP-8 location/presence
Evidence on MMP-8 by lesion depth or location was very low certainty.
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Outer/shallower carious dentin vs Inner/deeper carious dentin MMP-8 location/presence · Human carious dentin Evidence on MMP-8 by lesion depth or location was very low certainty. Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex… (2023) All outcomes | No clear single direction for MMP-8 by lesion depth/location (Kuhn 2016 NS by location; Shimada 2009 higher in outer); very low | 2 studies | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo studies. 2023 All outcomes | March 2022 | 18 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.