Question · asked by 1 review
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin: Adverse effects of antibiotics: severe cough
- Population
- adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
- Intervention
- Oral ciprofloxacin and inhaled colistin
- Comparison
- inhaled tobramycin
- Outcome
- Adverse effects of antibiotics: severe cough
It is very uncertain whether oral ciprofloxacin and inhaled colistin changes adverse effects of antibiotics: severe cough compared with inhaled tobramycin (TNS) (very low certainty).
What each review found
Current versions onlyNo studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) Adverse effects of antibiotics: severe cough · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… It is very uncertain whether oral ciprofloxacin and inhaled colistin changes adverse effects of antibiotics: severe cough compared with inhaled tobramycin (TNS) (very low certainty). Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2023) · Cochrane Headline outcomes only | OR 0.32 [0.01, 8.24] | 1 study · 58 participants | Very low |
Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin Adverse effects to antibiotics: severe cough · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory… It is very uncertain whether oral ciprofloxacin and inhaled colistin changes adverse effects to antibiotics: severe cough compared with inhaled tobramycin (very low certainty). Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis (2017) · Cochrane Headline outcomes onlyearlier version CD004197.PUB5, superseded | OR 0.32 [0.01, 8.24] | 1 study · 581 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.