Proton pump inhibitors (PPI) vs control: Increase in the number of participants with simple (diffuse) hyperplasia after treatment
It is very uncertain whether proton pump inhibitor changes increase in the number of participants with simple (diffuse)… compared with control (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Proton pump inhibitor vs control Increase in the number of participants with simple (diffuse) hyperplasia after treatment · people with pre‐malignant lesions It is very uncertain whether proton pump inhibitor changes increase in the number of participants with simple (diffuse)… compared with control (very low certainty). Long‐term proton pump inhibitor (PPI) use and the development of gastric pre‐malignant lesions (2014) · Cochrane Headline outcomes only | OR 5.01 [1.54, 16.26] | 6 studies · 1705 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Long‐term proton pump inhibitor (PPI) use and the development of gastric pre‐malignant lesions 2014 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.