NSAIDs vs paracetamol: Gastrointestinal adverse events
NSAID showed no clear difference in gastrointestinal adverse events compared with paracetamol (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
NSAID vs paracetamol Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain NSAID showed no clear difference in gastrointestinal adverse events compared with paracetamol (low certainty). Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury (2020) · Cochrane Headline outcomes only | RR 1.34 [0.97, 1.86] | 10 studies · 1504 participants | Low |
Summary of findings: NSAIDs vs paracetamol Gastrointestinal adverse events · people with acute soft tissue injury, such as ankle sprain Summary of findings: NSAIDs showed no clear difference in gastrointestinal adverse events compared with paracetamol (low certainty). Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury (2015) · Cochrane Headline outcomes onlyearlier version CD007789.PUB2, superseded | RR 1.76 [0.99, 3.14] | 7 studies · 627 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.