Question · asked by 1 review

Vaccination vs placebo: Serious adverse events among subjects in the adverse event substudy clinical manifestations

Vaccination leads to higher serious adverse events among subjects in the adverse event substudy… compared with placebo (high certainty).

What each review found

Current versions only
FindingEffectStudiesGRADE certainty
Vaccination vs placebo
Serious adverse events among subjects in the adverse event substudy clinical manifestations · people at risk for postherpetic neuralgia
Vaccination leads to higher serious adverse events among subjects in the adverse event substudy… compared with placebo (high certainty).
Vaccination for preventing postherpetic neuralgia (2011) · Cochrane Headline outcomes only
RR 1.53 [1.03, 2.25]1 study · 6616 participantsHigh

Findings are shown side by side, never pooled across reviews.

The reviews

ReviewSearched up toIncluded studiesAMSTAR 2
Vaccination for preventing postherpetic neuralgia
2011 · Cochrane Headline outcomes only
Not reportedlist not extracted yetNot assessed

Studies behind the findings

None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.

How reviews are matched to this question

Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.