Inhaled NO vs placebo: Frequency of pain crises in the
Inhaled nitric oxide showed no clear difference in frequency of pain crises in the compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Inhaled nitric oxide vs placebo Frequency of pain crises in the · adults and children with SCD Inhaled nitric oxide showed no clear difference in frequency of pain crises in the compared with placebo (low certainty). Inhaled nitric oxide for treating pain crises in people with sickle cell disease (2022) · Cochrane Headline outcomes only | RR 0.73 [0.31, 1.71] | 1 study · 150 participants | Low |
Inhaled nitric oxide vs placebo Frequency of pain crises in the · adults and children with SCD Inhaled nitric oxide showed no clear difference in frequency of pain crises in the compared with placebo (low certainty). Inhaled nitric oxide for treating pain crises in people with sickle cell disease (2022) · Cochrane Headline outcomes only | RR 0.53 [0.25, 1.11] | 1 study · 150 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Inhaled nitric oxide for treating pain crises in people with sickle cell disease 2022 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.