Tramadol in combination with acetaminophen vs placebo: Withdrawals due to adverse events
- Population
- patients with osteoarthritis
- Intervention
- Tramadol in combination with acetaminophen
- Comparison
- placebo
- Outcome
- Withdrawals due to adverse events
Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Tramadol in combination with acetaminophen vs placebo Number of participants who withdrew due to adverse events · osteoarthritis Tramadol in combination with acetaminophen may leads to higher number of participants who withdrew due to adverse events compared with placebo (low certainty). Tramadol for osteoarthritis (2019) · Cochrane Headline outcomes only | RR 2.78 [1.5, 5.16] | 2 studies · 614 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Tramadol for osteoarthritis 2019 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Tramadol in combination with acetaminophen vs NSAIDs · patients with osteoarthritis · 1 review
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How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.