Question · asked by 1 review
0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine: Speed of onset of anaesthesia (soft tissue, simulated)
- Population
- Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which dental local anaesthesia was tested
- Intervention
- 0.5% bupivacaine, 1:200,000 epinephrine
- Comparison
- 2% lidocaine, 1:100,000 epinephrine
- Outcome
- Speed of onset of anaesthesia (soft tissue, simulated)
It is very uncertain whether 0.5% bupivacaine, 1:200,000 epinephrine changes speed of onset of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
0.5% bupivacaine, 1:200,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine Speed of onset of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario… It is very uncertain whether 0.5% bupivacaine, 1:200,000 epinephrine changes speed of onset of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty). Injectable local anaesthetic agents for dental anaesthesia (2018) · Cochrane All outcomes | MD 0.02 [-1.07, 1.10] | 3 studies · 79 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Injectable local anaesthetic agents for dental anaesthesia 2018 · Cochrane All outcomes | 2018-01 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.