Topical plus systemic prophylaxis vs placebo or no treatment: Respiratory infections
Topical plus systemic prophylaxis probably leads to lower respiratory tract infections compared with placebo or no treatment (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Topical plus systemic prophylaxis vs placebo or no treatment Respiratory tract infections · adults receiving mechanical ventilation for at least 48 hours Topical plus systemic prophylaxis probably leads to lower respiratory tract infections compared with placebo or no treatment (moderate certainty). Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving… (2021) · Cochrane Headline outcomes only | RR 0.43 [0.35, 0.53] | 17 studies · 2951 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical ventilation 2021 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.