Question · asked by 1 review
An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week): HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth
- Population
- Breastfeeding infants of HIV‐infected mothers
- Intervention
- An extended NVP regimen administered to infants for 14 weeks
- Comparison
- sdNVP plus ZDV (1 week)
- Outcome
- HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth
An extended NVP regimen administered to infants for 14 weeks probably leads to lower HIV Transmission at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1week) (moderate certainty).
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1week) HIV Transmission at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers An extended NVP regimen administered to infants for 14 weeks probably leads to lower HIV Transmission at 9 months among those whose HIV diagnostic… compared with sdNVP plus ZDV (1week) (moderate certainty). Antiretroviral interventions for preventing breast milk transmission of HIV (2014) · Cochrane Headline outcomes only | HR 0.56 [0.41, 0.76] | 1 study · 2019 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.