Question · asked by 1 review
Systemic oral acyclovir vs placebo or no treatment: Duration of fever
- Population
- Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis)
- Intervention
- Systemic oral acyclovir
- Comparison
- placebo or no treatment
- Outcome
- Duration of fever
What each review found
Current versions only| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Systemic oral acyclovir vs Placebo or no treatment Fever (duration; time to return to normal temperature) · Children and young adults under 25 years with primary herpetic gingivostomatitis (with or without herpes labialis) Acyclovir for treating primary herpetic gingivostomatitis (2008) · Cochrane All outcomes | Amir 1997b: fever disappeared significantly earlier with acyclovir (median 1 day) than placebo (median 3 days); difference in median (95% CI): From 72: 1 (0.0 to 2.0); From 61: 2 (0.8 to 3.2); reported as median, not… | 2 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Acyclovir for treating primary herpetic gingivostomatitis 2008 · Cochrane All outcomes | 2008-05 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.